Endocrine Abstracts

It was established that androgens are able to modulate luteal function during pregnancy by stimulation of corpus luteum (CL) progesterone release. In pigs, CL is the main source of progesterone through the entire gestation. Our previous study revealed that porcine CL is capable of androgen synthesis during second half of pregnancy. Therefore, we suggest that androgens, in addition to progesterone, are essential for the maintenance of pregnancy in pigs.Th...

Objective: The impact of first-line somatostatin analogues (SSA) on glucose tolerance in acromegaly was investigated during a 10 year period.Patients: One hundred and twelve patients treated with depot SSA.Outcome measures: Primary outcome measures were fasting glucose levels. Data were analyzed according with baseline glucose tolerance and disease control.Results after 12 months SSA treatment: In the 63 pati...

Elevated insulin levels are correlated with colonic adenomas and carcinomas in the general population. Patients with acromegaly are considered at high risk to develop colonic lesions and have a high insulin levels. To evaluate the role of insulin levels on colonic polyps (hyperplastic, adenomatous, single or synchronous) or adenocarcinoma in acromegaly we designed this analytical, observational, open, prospective, study enrolling 189 patients (100 women, 89 men, age 20–82...

The most frequent cause of death in acromegaly is cardiomyopathy. To evaluate determinants of the acromegalic cardiomyopathy we performed an analytical, observational, open, prospective, controlled study in 205 patients with active acromegaly (108 women and 97 men) and 205 non-acromegalic subjects sex- and age-matched with the patients. We determined the prevalence of Left Ventricular (LV) hypertrophy (LVH), diastolic and systolic dysfunction, by echocardiography- measured LV ...

Growth hormone (GH) is an important factor involved in the regulation of multiple biological functions. Although the influence of GH is widespread throughout several organs and tissues, the effects of GH on brain functions, such as those related to reproductive functions, are still elusive. GH deficiency or resistance can be related to late puberty onset, lack of sexual maturation and infertility. In contrast, GH therapy can accelerate puberty onset or be used to increase preg...

Background and aims: Cerebrovascular reactivity (CVR) impairment was reported as a marker of cerebral microangiopathy in long-term type 1 diabetes (DM1). Indices of cerebral blood flow might serve as an indicator of early microangiopathic complications. The aim of this study was to evaluate CVR in patients with DM1 and diabetic nephropathy. Research design and methods: Study has been reviewed by the Local Ethics Committee. The study has been performed in accordance with ethica...

Introduction: Urgent conditions, as first symptom of endocrine disease, are rather rare in a hospital emergency department. Emergency medicine doctors work in difficult conditions, often under time pressure, they must also be guided by the likelihood of linking symptoms to the disease. Unfortunately, this makes it difficult to diagnose rare diseases. Therefore, without criticising doctors of other specialties, we would like to present our patient’s long journey from the e...

Multiple benign symmetric lipomatosis (Madelung’s disease, Launois–Bensaude syndrome) is significantly rare disease characterised by symmetrical focal deposition of adipose tissue in the neck, upper part of the arms, back, pelvis, and thigh. Although its etiology is uncertain, it has been associated with genetic factors, mitochondrial inheritance and alcoholism. Its pathogenesis seems to include a dysfunction of cAMP and levels of catecholamines in adipocytes. This c...

It is well established that the kisspeptins are the main activators of GnRH neurons and therefore essential for the onset of puberty and reproduction. Previous studies have suggested that kisspeptin neurons are possibly major targets of pro-inflammatory cytokines to regulate reproduction. SOCS (suppressor of cytokine signaling) are proteins that regulate, as it says, cytokines. They inhibit the transduction of intracellular effects caused by those molecules, once that cytokine...

Type 1 diabetes mellitus (T1DM) is one of the most frequent autoimmune disorders in childhood, adolescence and youth, developing due to autoimmune destruction of pancreatic β-cells, which leads to an absolute insulin deficiency. Gut microbiota (GM) is associated with the functions of the body’s immune system, and immune-mediated diseases, including T1DM. However, the exact mechanisms by which GM is involved in the T1DM are still unknown. Accumulating data suggest tha...